Back to search

Article

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

2020-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has led to accelerated efforts to develop therapeutics, diagnostics, and vaccines to mitigate this public health emergency. A key target of these efforts is the spike (S) protein, a large trimeric class I fusion protein that is metastable and difficult to produce recombinantly in large quantities. Here, we designed and expressed ov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
07e6847e-58fb-5bd0-ab7b-8625f840ee60
DOI
10.1101/2020.05.30.125484
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Structure-based Design of Prefusion-stabilized SARS-CoV-2 SpikesDOI 10.1101/2020.05.30.125484
Structure-based design of prefusion-stabilized SARS-CoV-2 spikesSemantic proximity
Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity
Stabilizing the Closed SARS-CoV-2 Spike TrimerSemantic proximity
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike.Semantic proximity
Prefusion spike protein stabilization through computational mutagenesisSemantic proximity
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopesSemantic proximity
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity
Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensSemantic proximity
Prefusion spike protein stabilization through computational mutagenesis.Semantic proximity
SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicitySemantic proximity
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.Semantic proximity
Structural impact on SARS-CoV-2 spike protein by D614G substitutionSemantic proximity
Select a neighboring publication to make it the new centre.