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Article

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike.

Nature communications - 10 Apr 2023

Tan Timothy J C, Mou Zongjun, Lei Ruipeng, Ouyang Wenhao O, Yuan Meng, Song Ge, Andrabi Raiees, Wilson Ian A, Kieffer Collin, Dai Xinghong, Matreyek Kenneth A, Wu Nicholas C

Abstract excerpt

Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary methods on engineering prefusion-stabilized spike immunogens involve tedious experimental work and heavily rely on structural information. Here, we establish a systematic and...

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Identifiers

PMID: 37037866
DOI: 10.1038/s41467-023-37786-1
PMCID: PMC10086000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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