Article

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

2021-07-11

Abstract excerpt

Current COVID-19 vaccines and many clinical diagnostics are based on the structure and function of the SARS-CoV-2 spike ectodomain. Using hydrogen deuterium exchange mass spectrometry, we have uncovered that, in addition to the prefusion structure determined by cryo-EM, this protein adopts an alternative conformation that interconverts slowly with the canonical prefusion structure. This new conformation—an open tr...

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Literature Corpus work: b3fa371b-6160-545b-b097-8cf04497b1d7
DOI: 10.1101/2021.07.11.451855

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