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SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity

27 Aug 2021

Abstract excerpt

The SARS-CoV-2 spike is the primary target of virus-neutralizing antibodies and critical to the development of effective vaccines against COVID-19. Here, we demonstrate that the prefusion-stabilized two-proline "S2P" spike-widely employed for laboratory work and clinical studies-unfolds when stored at 4 °C, physiological pH, as observed by electron microscopy (EM) and differential scanning calorimetry, but that...

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PMID: 34461095
DOI: 10.1016/j.jbc.2021.101127

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