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Structural impact on SARS-CoV-2 spike protein by D614G substitution

16 Mar 2021

Abstract excerpt

Substitution for aspartic acid (D) by glycine (G) at position 614 in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to facilitate rapid viral spread. The G614 strain and its recent variants are now the dominant circulating forms. Here, we report cryo-electron microscopy structures of a full-length G614 S trimer, which adopts three distinct prefusion conformations...

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Bacteriophages and microbial interactions
SARS-CoV-2 and COVID-19 Research
Viral gastroenteritis research and epidemiology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33727252
DOI: 10.1126/science.abf2303

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