Article

Prefusion spike protein stabilization through computational mutagenesis

2020-06-19

Abstract excerpt

<h4>ABSTRACT</h4> A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) has emerged as a human pathogen, causing global pandemic and resulting in over 400,000 deaths worldwide. The surface spike protein of SARS-CoV-2 mediates the process of coronavirus entry into human cells by binding angiotensin-converting enzyme 2 (ACE2). Due to the critical role in viral-host interaction and the expos...

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Literature Corpus work: a0e914e7-7dde-56db-8cd5-957b41f2d829
DOI: 10.1101/2020.06.17.157081

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