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Article

Stabilizing the closed SARS-CoV-2 spike trimer.

Nature communications - 11 Jan 2021

Juraszek Jarek, Rutten Lucy, Blokland Sven, Bouchier Pascale, Voorzaat Richard, Ritschel Tina, Bakkers Mark J G, Renault Ludovic L R, Langedijk Johannes P M

Abstract excerpt

The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yields. To support ongoing vaccine development efforts, we report the structure-based design of soluble S trimers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33431842
DOI: 10.1038/s41467-020-20321-x
PMCID: PMC7801441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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