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Article

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens

27 Aug 2024

Abstract excerpt

The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, S2's usage as an...

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PMID: 39191724
DOI: 10.1038/s41467-024-50976-9

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