Article
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.
Nature structural & molecular biology - 1 Oct 2020
McCallum Matthew, Walls Alexandra C, Bowen John E, Corti Davide, Veesler David
Abstract excerpt
SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface and fusion of the viral and host membranes. Prefusion SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of vaccine design. However, its limited stability...
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