Article

Stabilizing the Closed SARS-CoV-2 Spike Trimer

2020-07-10

Abstract excerpt

The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yields. To support ongoing vaccine development efforts, we report the structure-based design of soluble S trimers, wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5e8ba5f-065c-5595-84ca-36377d11f6ae
DOI: 10.1101/2020.07.10.197814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stabilizing the Closed SARS-CoV-2 Spike TrimerDOI 10.1101/2020.07.10.197814Read

Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity Read

A thermostable, closed SARS-CoV-2 spike protein trimer.Semantic proximity Read

A thermostable, closed, SARS-CoV-2 spike protein trimerSemantic proximity Read

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.Semantic proximity Read

Structure-based Design of Prefusion-stabilized SARS-CoV-2 SpikesSemantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensSemantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike Variants.Semantic proximity Read

Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein coreSemantic proximity Read

Structural impact on SARS-CoV-2 spike protein by D614G substitutionSemantic proximity Read

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.Semantic proximity Read