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Article

Prefusion spike protein stabilization through computational mutagenesis.

Proteins - 1 Apr 2021

Zhang Dong Yan, Wang Jian, Dokholyan Nikolay V

Abstract excerpt

A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) has emerged as a human pathogen, causing global pandemic and resulting in over 400 000 deaths worldwide. The surface spike protein of SARS-CoV-2 mediates the process of coronavirus entry into human cells by binding angiotensin-converting enzyme 2 (ACE2). Due to the critical role in viral-host interaction and the exposure of spike...

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Source

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Identifiers

PMID: 33231324
DOI: 10.1002/prot.26025
PMCID: PMC7753443

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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