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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

23 Jul 2020

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is metastable and difficult to produce recombinantly. We characterized 100 structure-guided spike designs and identified 26 individual substitutions that increased protein yields and stability. Testing combinations of beneficial...

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PMID: 32703906
DOI: 10.1126/science.abd0826

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