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Characterization of the Rat Osteosarcoma Cell Line UMR-106 by Long Read Technologies Identifies a Large Block of Amplified Genes Associated with Human Disease

2024-09-24

Abstract excerpt

The rat osteosarcoma cell line UMR-106 is widely used for the study of bone cancer biology. We have characterized UMR-106 with a combination of optical genome mapping (OGM), long-read sequencing (for identification of variants and 5mC methylation), and short-read RNA sequencing for expression. Genome sequence was compared to a Sprague-Dawley control animal, the strain from which UMR-106 was derived, and expression...

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Literature Corpus work
06f94e07-abb4-51c7-9db5-36f013be009b
DOI
10.20944/preprints202409.0416.v2
Open publication

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Characterization of the Rat Osteosarcoma Cell Line UMR-106 by Long Read Technologies Identifies a Large Block of Amplified Genes Associated with Human DiseaseDOI 10.20944/preprints202409.0416.v2
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