Article

Integrated multi-omic analysis of pediatric metastatic osteosarcoma reveals endothelial cell plasticity and lineage infidelity

2026-08-12

Abstract excerpt

<h4>ABSTRACT</h4> While recent research has increasingly focused on the role of fibroblasts and macrophages in osteosarcoma, the tumor vasculature remains poorly understood, particularly in metastatic disease. To address this gap, we performed single-nuclei multi-ome (RNA+ATAC) sequencing on 24 human metastatic osteosarcoma specimens. We found that endothelial cells adopt a hybrid endothelial-mesenchymal state re...

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Literature Corpus work: d83c9777-9873-552d-8fa3-c8f7072f7515
DOI: 10.64898/2026.08.11.744222

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