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Article

The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis.

Genes, chromosomes & cancer - 1 Jul 2024

Meijer Debora M, Ruano Dina, Briaire-de Bruijn Inge H, Wijers-Koster Pauline M, van de Sande Michiel A J, Gelderblom Hans, Cleton-Jansen Anne-Marie, de Miranda Noel F C C, Kuijjer Marieke L, Bovée Judith V M G

Abstract excerpt

Osteosarcoma is a primary bone tumor that exhibits a complex genomic landscape characterized by gross chromosomal abnormalities. Osteosarcoma patients often develop metastatic disease, resulting in limited therapeutic options and poor survival rates. To gain knowledge on the mechanisms underlying osteosarcoma heterogeneity and metastatic process, it is important to obtain a detailed profile of the genomic...

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Identifiers

PMID: 39023390
DOI: 10.1002/gcc.23253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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