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Characterization of the Rat Osteosarcoma Cell Line UMR-106 by Long-Read Technologies Identifies a Large Block of Amplified Genes Associated with Human Disease.

Genes - 26 Sept 2024

Scott Alan F, Mohr David W, Littrell William A, Babu Reshma, Kokosinski Michelle, Stinnett Victoria, Madhiwala Janvi, Anderson John, Zou Ying S, Gabrielson Kathleen L

Abstract excerpt

BACKGROUND/OBJECTIVES: The rat osteosarcoma cell line UMR-106 is widely used for the study of bone cancer biology but it has not been well characterized with modern genomic methods. METHODS: To better understand the biology of UMR-106 cells we used a combination of optical genome mapping (OGM), long-read sequencing nanopore sequencing and RNA sequencing.The UMR-106 genome was compared to a strain-matched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39457378
DOI: 10.3390/genes15101254
PMCID: PMC11507229

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