Article
A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.
Cell genomics - 10 Apr 2024
de Jong Tristan V, Pan Yanchao, Rastas Pasi, Munro Daniel, Tutaj Monika, Akil Huda, Benner Chris, Chen Denghui, Chitre Apurva S, Chow William, Colonna Vincenza, Dalgard Clifton L, Demos Wendy M, Doris Peter A, Garrison Erik, Geurts Aron M, Gunturkun Hakan M, Guryev Victor, Hourlier Thibaut, Howe Kerstin, Huang Jun, Kalbfleisch Ted, Kim Panjun, Li Ling, Mahaffey Spencer, Martin Fergal J, Mohammadi Pejman, Ozel Ayse Bilge, Polesskaya Oksana, Pravenec Michal, Prins Pjotr, Sebat Jonathan, Smith Jennifer R, Solberg Woods Leah C, Tabakoff Boris, Tracey Alan, Uliano-Silva Marcela, Villani Flavia, Wang Hongyang, Sharp Burt M, Telese Francesca, Jiang Zhihua, Saba Laura, Wang Xusheng, Murphy Terence D, Palmer Abraham A, Kwitek Anne E, Dwinell Melinda R, Williams Robert W, Li Jun Z, Chen Hao
Abstract excerpt
The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor. Gene annotations are now more complete, improving the mapping precision of genomic, transcriptomic, and proteomics datasets. We jointly analyzed 163 short-read...
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