Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.

Genes & development - 15 Sept 2017

Pourebrahim Rasoul, Zhang Yun, Liu Bin, Gao Ruli, Xiong Shunbin, Lin Patrick P, McArthur Mark J, Ostrowski Michael C, Lozano Guillermina

Abstract excerpt

TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we developed a traceable somatic osteosarcoma mouse model that is initiated with either a single p53 mutation (p53R172H) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Neoplasm Metastasis

Share to Osteoblasts

Share to Osteosarcoma

Share to RNA, Small Nucleolar

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 29021240
DOI: 10.1101/gad.304972.117
PMCID: PMC5695086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.PMID 29021240Read ↗

Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma.Semantic proximity Read ↗

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants.Semantic proximity Read ↗

Whole-Exome Analysis and Osteosarcoma: A Game Still Open.Semantic proximity Read ↗

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.Semantic proximity Read ↗

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.Semantic proximity Read ↗

Transposon mutagenesis disentangles osteosarcoma genetic drivers.Semantic proximity Read ↗

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers <i>Skp2</i> function in metastasis, genomic instability and immune activation and reveals additional target pathwaysSemantic proximity Read ↗

Snord67 promotes lymph node metastasis and regulates U6-mediated alternative splicing in breast cancerSemantic proximity Read ↗

Small Nucleolar RNAs as Emerging Players in Cancer Biology and Precision MedicineSemantic proximity Read ↗

SKP2 Knockout in Rb1/p53–Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable PrognosisSemantic proximity Read ↗

Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.Semantic proximity Read ↗

Characterization of the Rat Osteosarcoma Cell Line UMR-106 by Long Read Technologies Identifies a Large Block of Amplified Genes Associated with Human DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.