Article
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.
Nature genetics - 1 Jun 2015
Moriarity Branden S, Otto George M, Rahrmann Eric P, Rathe Susan K, Wolf Natalie K, Weg Madison T, Manlove Luke A, LaRue Rebecca S, Temiz Nuri A, Molyneux Sam D, Choi Kwangmin, Holly Kevin J, Sarver Aaron L, Scott Milcah C, Forster Colleen L, Modiano Jaime F, Khanna Chand, Hewitt Stephen M, Khokha Rama, Yang Yi, Gorlick Richard, Dyer Michael A, Largaespada David A
Abstract excerpt
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with a high propensity to metastasize. Osteosarcoma is associated with massive genomic instability, making it problematic to identify driver genes using human tumors or prototypical mouse models, many of which involve loss of Trp53 function. To identify the genes driving osteosarcoma development and metastasis, we performed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.