Article

Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humans

2026-04-28

Abstract excerpt

Osteosarcoma (OS) genomes are characterized by complex genomic rearrangements (CGRs) that drive genomic instability and clonal diversification early in tumor evolution. As a result, OS tumors display high inter-patient variability, which has hindered molecular stratification and targeted therapeutic development. To study genomic complexity in OS and credential a genetically engineered mouse model of the disease (...

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Identifiers and source

Literature Corpus work: 732a388e-ef69-5151-9e60-b12473f86a01
DOI: 10.64898/2026.04.27.721100

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