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Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

2021-07-30

Abstract excerpt

Many non-coding genetic variants cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated by gene-regulation differences between cell states. T cells, for example, have fluid, multifaceted functional states in vivo that cannot be modeled in eQTL studies that aggregate cells. Here, we modeled T cell states and eQTLs at single-cell resolution....

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Literature Corpus work: 056c22f9-3b40-588b-ad57-f0cca55ec5d6
DOI: 10.1101/2021.07.29.454316

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