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Article

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.

Nature - 1 Jun 2022

Nathan Aparna, Asgari Samira, Ishigaki Kazuyoshi, Valencia Cristian, Amariuta Tiffany, Luo Yang, Beynor Jessica I, Baglaenko Yuriy, Suliman Sara, Price Alkes L, Lecca Leonid, Murray Megan B, Moody D Branch, Raychaudhuri Soumya

Abstract excerpt

Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated by differences in gene regulation across fluid functional cell states within cell types. These states-for example, neurotransmitter-driven programs in astrocytes or perivascular fibroblast differentiation-are obscured in eQTL studies that aggregate...

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Identifiers

PMID: 35545678
DOI: 10.1038/s41586-022-04713-1
PMCID: PMC9842455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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