Article
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
Nature genetics - 1 Dec 2023
Kang Joyce B, Shen Amber Z, Gurajala Saisriram, Nathan Aparna, Rumker Laurie, Aguiar Vitor R C, Valencia Cristian, Lagattuta Kaitlyn A, Zhang Fan, Jonsson Anna Helena, Yazar Seyhan, Alquicira-Hernandez Jose, Khalili Hamed, Ananthakrishnan Ashwin N, Jagadeesh Karthik, Dey Kushal, Daly Mark J, Xavier Ramnik J, Donlin Laura T, Anolik Jennifer H, Powell Joseph E, Rao Deepak A, Brenner Michael B, Gutierrez-Arcelus Maria, Luo Yang, Sakaue Saori, Raychaudhuri Soumya
Abstract excerpt
The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, regulatory genetic variation modulating HLA expression levels has not been comprehensively investigated. Here we mapped expression quantitative trait loci (eQTLs) for classical HLA genes across...
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