Article

Single-cell RNA sequencing reveals cell-type specific <i>cis</i> -eQTLs in peripheral blood mononuclear cells

2017-08-17

Abstract excerpt

Most disease-associated genetic risk factors are regulatory. Here, we generated single-cell RNA-seq data of ∼25,000 peripheral blood mononuclear cells from 45 donors to identify how genetic variants affect gene expression. We validated this approach by replicating previously published whole blood RNA-seq cis- expression quantitative trait loci effects ( cis- eQTLs), but also identified new cell type-specific ci...

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Identifiers and source

Literature Corpus work: 0026857f-a144-5f1e-8654-c9f89b75d6c4
DOI: 10.1101/177568

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