Article
Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.
Science (New York, N.Y.) - 8 Apr 2022
Yazar Seyhan, Alquicira-Hernandez Jose, Wing Kristof, Senabouth Anne, Gordon M Grace, Andersen Stacey, Lu Qinyi, Rowson Antonia, Taylor Thomas R P, Clarke Linda, Maccora Katia, Chen Christine, Cook Anthony L, Ye Chun Jimmie, Fairfax Kirsten A, Hewitt Alex W, Powell Joseph E
Abstract excerpt
The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing (scRNA-seq) data from 1,267,758 peripheral blood mononuclear cells from 982 healthy human subjects. For 14 cell types, we identified 26,597 independent cis-expression quantitative trait loci (eQTLs) and 990 trans-eQTLs, with most showing...
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