Article
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Nature immunology - 1 Jun 2021
Nathan Aparna, Beynor Jessica I, Baglaenko Yuriy, Suliman Sara, Ishigaki Kazuyoshi, Asgari Samira, Huang Chuan-Chin, Luo Yang, Zhang Zibiao, Lopez Kattya, Lindestam Arlehamn Cecilia S, Ernst Joel D, Jimenez Judith, Calderón Roger I, Lecca Leonid, Van Rhijn Ildiko, Moody D Branch, Murray Megan B, Raychaudhuri Soumya
Abstract excerpt
Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis (TB) progression cohort. At immune steady state >4 years after infection and disease resolution, we found that, after accounting for...
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