Article

Mapping the dynamic genetic regulatory architecture of<i>HLA</i>genes at single-cell resolution

2023-03-20

Abstract excerpt

The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation, and cancer. While coding variation in HLA genes has been extensively documented, regulatory genetic variation modulating HLA expression levels has not been comprehensively investigated. Here, we mapped expression quantitative trait loci (eQTLs) for classical HLA genes across...

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Literature Corpus work: 845741c4-b1e0-5afb-881f-f664a680c67b
DOI: 10.1101/2023.03.14.23287257

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