Article

Dynamic regulatory elements in single-cell multimodal data capture autoimmune disease heritability and implicate key immune cell states

2023-03-01

Abstract excerpt

In autoimmune diseases such as rheumatoid arthritis (RA), the immune system attacks host tissues 1-3 . Developing a precise understanding of the fine-grained cell states that mediate the genetics of autoimmunity is critical to uncover causal disease mechanisms and develop potentially curative therapies. We leveraged multimodal single-nucleus (sn) RNA-seq and ATAC-seq data across 28,674 cells from the inflamed syn...

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Literature Corpus work: 54ee73c7-9343-5744-b92d-bfad3835136f
DOI: 10.1101/2023.02.24.23286364

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