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T-dependent B cell responses to <i>Plasmodium</i> induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

2017-02-15

Abstract excerpt

The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-validated modeling to analyze the binding of a murine neutralizing antibody to Plasmodium falciparum CSP. Strikingly,...

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Literature Corpus work
04c0dac1-5e47-5c93-8b01-f91bfb1ae5b0
DOI
10.1101/108746
Open publication

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T-dependent B cell responses to <i>Plasmodium</i> induce antibodies that form a high-avidity multivalent complex with the circumsporozoite proteinDOI 10.1101/108746
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