Article

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

2019-10-18

Abstract excerpt

Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here we show that antibody titres to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein ( Pf CSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed Ig-kn...

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Literature Corpus work: 9cd702ef-45a1-5098-b7bb-ec9f1ac5907f
DOI: 10.1101/808543

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