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Article

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.

Science (New York, N.Y.) - 22 Jun 2018

Imkeller Katharina, Scally Stephen W, Bosch Alexandre, Martí Gemma Pidelaserra, Costa Giulia, Triller Gianna, Murugan Rajagopal, Renna Valerio, Jumaa Hassan, Kremsner Peter G, Sim B Kim Lee, Hoffman Stephen L, Mordmüller Benjamin, Levashina Elena A, Julien Jean-Philippe, Wardemann Hedda

Abstract excerpt

Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antibodies against the circumsporozoite protein of the malaria parasite Plasmodium falciparum (PfCSP). We show in...

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Share to Antibodies, Protozoan
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29880723
DOI: 10.1126/science.aar5304
PMCID: PMC6420115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.PMID 29880723Read ↗

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