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Avid binding by B cells to the <i>Plasmodium</i> circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

2020-01-13

Abstract excerpt

Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSP Repeat ) can confer protection against malaria. However, it has also been suggested that this repeat domain exists as a decoy that distracts the immune system from mounting protective responses targeting other domains of CSP. Here we show that B cell responses to the repeat domain are indeed ∼10 fold highe...

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Identifiers and source

Literature Corpus work
05c89873-5540-5c55-98ec-b655c323a9ab
DOI
10.1101/2020.01.12.903682
Open publication

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Avid binding by B cells to the <i>Plasmodium</i> circumsporozoite protein repeat suppresses responses to protective subdominant epitopesDOI 10.1101/2020.01.12.903682
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