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Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against <i>Plasmodium</i> sporozoite infection

2022-06-17

Abstract excerpt

Malaria-causing Plasmodium parasites have a complex life cycle and present numerous antigen targets that may contribute to protective immune responses. The currently recommended vaccine—RTS,S—functions by targeting the P. falciparum circumsporozoite protein (CSP), which is the most abundant surface protein of the sporozoite form responsible for initiating infection of the human host. Despite showing only moderat...

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Literature Corpus work
48aa68b3-0cab-585e-8d22-c4a3a1c164c7
DOI
10.1101/2022.06.17.496580
Open publication

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Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against <i>Plasmodium</i> sporozoite infectionDOI 10.1101/2022.06.17.496580
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