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Proteolytic Cleavage of the<i>Plasmodium falciparum</i>Circumsporozoite Protein Is a Target of Protective Antibodies

11 Mar 2015

Abstract excerpt

Studies in animals and human volunteers demonstrate that antibodies against the repeat-region of the Plasmodium circumsporozoite protein (CSP) abrogate sporozoite infection. However, the realization that the N- and C- terminal regions flanking the repeats play essential roles in parasite infectivity raised the possibility that they could be targeted by protective antibodies. We characterized a monoclonal antibody...

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PMID: 25762791
DOI: 10.1093/infdis/jiv154

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