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Structural and biophysical correlation of anti-NANP antibodies with <i>in vivo</i> protection against <i>P. falciparum</i>

2020-07-18

Abstract excerpt

The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine, RTS,S/AS01 (RTS,S), confers partial protection but with antibody titers that wane relatively rapidly, highlighting the need to elicit more potent and durable antibody responses. Here, we elucidate crystal structures, binding affinities and kinetics, and in vivo protection of eight anti-NANP antibodies (Abs) derived from an RT...

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Literature Corpus work
1d50fb32-a6e1-55bb-8fc6-4f144e03602a
DOI
10.1101/2020.07.18.210385
Open publication

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Structural and biophysical correlation of anti-NANP antibodies with <i>in vivo</i> protection against <i>P. falciparum</i>DOI 10.1101/2020.07.18.210385
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