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Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

1 Apr 2021

Abstract excerpt

Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSP Repeat ) can protect against malaria. However, it has also been suggested that the CSP Repeat is a decoy that prevents the immune system from mounting responses against other domains of CSP. Here, we show that, following parasite immunization, B cell responses to the CSP Repeat are immunodominant over...

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PMID: 33852850
DOI: 10.1016/j.celrep.2021.108996

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