Article

Evolution of protective human antibodies against <i>Plasmodium falciparum</i> circumsporozoite protein repeat motifs

2019-10-09

Abstract excerpt

<h4>SUMMARY</h4> Circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease. Protective antibodies recognize the central PfCSP domain, but our understanding of how parasite inhibition is associated with recognition of this domain and with the evolution of potent antibodies remains scattered. Here, we characterized t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04869ee5-3975-5bae-9766-a0ef106376fd
DOI: 10.1101/798769

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution of protective human antibodies against <i>Plasmodium falciparum</i> circumsporozoite protein repeat motifsDOI 10.1101/798769Read

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparumSemantic proximity Read

Structural and biophysical correlation of anti-NANP antibodies with <i>in vivo</i> protection against <i>P. falciparum</i>Semantic proximity Read

Molecular and functional properties of human <i>Plasmodium falciparum</i> CSP C-terminus antibodiesSemantic proximity Read

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity Read

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodiesSemantic proximity Read

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infectionSemantic proximity Read

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity Read

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite ProteinSemantic proximity Read

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.Semantic proximity Read

Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccineSemantic proximity Read

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malariaSemantic proximity Read

Clonal evolution and specificity of the human T follicular helper cell response to <i>Plasmodium falciparum</i> circumsporozoite proteinSemantic proximity Read