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Dysfunctional memory B cell responses to the protective repeat region of the <i>Plasmodium</i> circumsporozoite protein are associated with waning humoral immunity

2025-12-22

Abstract excerpt

Malaria vaccines provide waning protection from disease that is correlated with the production of antibodies to the repeat region of the liver-stage circumsporozoite protein (CSP). CSP-based vaccines display limited durability in malaria-naïve individuals yet are even less effective in malaria-experienced individuals, suggesting the generation of non-optimal humoral immunity in response to both infection and vacci...

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Identifiers and source

Literature Corpus work
2f3d9bbe-cd52-51ed-9a23-85eca4384176
DOI
10.64898/2025.12.19.695559
Open publication

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