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Machine learning enables <i>de novo</i> multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

2025-07-01

Abstract excerpt

<h4> Abstract </h4> Currently approved vaccines for the prevention of malaria provide only partial protection against disease, due to high variability in the quality of induced antibodies. These vaccines present the unstructured central repeat region, as well as the C-terminal domain, of the circumsporozoite protein ( Pf CSP) of the malaria parasite, Plasmodium falciparum (1). A recently discovered protective...

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Identifiers and source

Literature Corpus work
e9bfaca2-882b-59f5-96c2-50b1e74b35de
DOI
10.1101/2025.06.29.662177
Open publication

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