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Article

Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk.

PLoS computational biology - 1 Jun 2025

Hu Jiaqi, Ye Yixuan, Zhang Chi, Ruan Yunfeng, Natarajan Pradeep, Zhao Hongyu

Abstract excerpt

BACKGROUND: Polygenic risk score (PRS) have proved to offer robust risk prediction for coronary artery disease (CAD). However, the global CAD PRS summarizes the joint effects of all the markers in the genome, masking potential genetic heterogeneity that may be important for disease interpretation and targeted interventions. METHODS: Using summary-level data, we identified 43 significant CAD-related traits based...

Read the complete abstract on PubMed

Topics

Humans
Coronary Artery Disease
Multifactorial Inheritance
Genetic Pleiotropy
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Risk Factors

Computational Biology

Male

Female

United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 40570042
DOI: 10.1371/journal.pcbi.1013191
PMCID: PMC12212871

Genes

CAD

Provenance

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