Article
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.
Nature medicine - 1 Jul 2023
Patel Aniruddh P, Wang Minxian, Ruan Yunfeng, Koyama Satoshi, Clarke Shoa L, Yang Xiong, Tcheandjieu Catherine, Agrawal Saaket, Fahed Akl C, Ellinor Patrick T, Tsao Philip S, Sun Yan V, Cho Kelly, Wilson Peter W F, Assimes Themistocles L, van Heel David A, Butterworth Adam S, Aragam Krishna G, Natarajan Pradeep, Khera Amit V
Abstract excerpt
Identification of individuals at highest risk of coronary artery disease (CAD)-ideally before onset-remains an important public health need. Prior studies have developed genome-wide polygenic scores to enable risk stratification, reflecting the substantial inherited component to CAD risk. Here we develop a new and significantly improved polygenic score for CAD, termed GPSMult, that incorporates genome-wide...
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