Article

Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancer

2019-11-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genetic variation can predispose to disease both through (i) monogenic risk variants in specific genes that disrupt a specific physiologic pathway and have a large effect on disease risk and (ii) polygenic risk that involves large numbers of variants of small effect that affect many different pathways. Few studies have explored the interaction between monogenic risk variants a...

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Literature Corpus work: 3dfb76b6-273e-5004-bc7c-52fd4e3024c6
DOI: 10.1101/19013086

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