Article
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology
European heart journal - 15 Apr 2025
Schunkert Heribert, Di Angelantonio Emanuele, Inouye Michael, Patel Riyaz S, Ripatti Samuli, Widen Elisabeth, Sanderson Saskia C, Kaski Juan Pablo, McEvoy John W, Vardas Panos, Wood Angela, Aboyans Victor, Vassiliou Vassilios S, Visseren Frank L J, Lopes Luis R, Elliott Perry, Kavousi Maryam
Abstract excerpt
Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (PRS) can capture this information in a single metric and hold promise for use in CVD risk prediction. Importantly, PRS information can reflect the causally mediated risk to which the individual is exposed throughout life. Although European Society of Cardiology...
Topics
- Humans
- Cardiovascular Diseases
- Risk Assessment
- Multifactorial Inheritance
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Risk Factors