Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis

Abstract excerpt

Hepatocellular carcinoma is the most prevalent primary liver cancer and arises from hepatocytes, which are very metabolically active and contain abundant mitochondria. Despite extensive characterisation of nuclear driver genes and pathways, the role of crosstalk between the mitochondrial and nuclear genomes in mitochondrial mutagenesis remains poorly understood. To address this, we leveraged a chemical carcinogene...

Topics

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• Diethylnitrosamine
• Disease Models, Animal
• DNA Copy Number Variations
• Exome
• Genes, ras
• Liver Neoplasms, Experimental
• Mice
• Mice, Inbred C3H

Identifiers and source

Literature Corpus work

049f8f93-7c33-5021-a240-dda54b8be70a

DOI

10.1101/2025.02.11.637769