Somatic evolution following cancer treatment in normal tissue.

doi:10.1038/s41586-025-09792-4

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Article

Somatic evolution following cancer treatment in normal tissue.

Nature - 1 May 2026

Pich Oriol, Ward Sophia, Rowan Andrew, Naceur-Lombardelli Cristina, Shutkever Oliver, Martinez-Ruiz Carlos, Harries Siân, Hessey Sonya, Naidu Babu, Brenton James D, Le Quesne John, Thomas Anne, Richards Cathy, Krebs Matthew G, Turajlic Samra, Jogai Sanjay, Zaccaria Simone, Moore David, Hiley Crispin T, Swanton Charles, Jamal-Hanjani Mariam, McGranahan Nicholas

Abstract excerpt

The extent to which exogenous sources, including cancer treatment, contribute to somatic evolution in normal tissue remains unclear. Here we used high-depth duplex sequencing1 (more than 30,000× coverage) to analyse 168 cancer-free samples representing 16 organs from 22 patients with metastatic cancer enroled in the PEACE research autopsy study. In every sample, we identified somatic mutations (range 305-2,854...

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