Article
Comprehensive molecular characterization of mitochondrial genomes in human cancers.
Nature genetics - 1 Mar 2020
Yuan Yuan, Ju Young Seok, Kim Youngwook, Li Jun, Wang Yumeng, Yoon Christopher J, Yang Yang, Martincorena Inigo, Creighton Chad J, Weinstein John N, Xu Yanxun, Han Leng, Kim Hyung-Lae, Nakagawa Hidewaki, Park Keunchil, Campbell Peter J, Liang Han
Abstract excerpt
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing...
Topics
- Cell Cycle
- DNA Copy Number Variations
- DNA Repair
- DNA, Mitochondrial
- Genome, Human
- Genome, Mitochondrial
- Humans
- Mutation
- Neoplasms
- Oxidative Phosphorylation