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Article

Understanding Mitochondrial Polymorphisms in Cancer.

Cancer research - 15 Nov 2017

Bussard Karen M, Siracusa Linda D

Abstract excerpt

Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, including cardiovascular disease, diabetes, and cancer. Furthermore, interplay between mtDNA and...

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PMID: 29097610
DOI: 10.1158/0008-5472.CAN-17-1939

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