Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.

Nature ecology & evolution - 1 May 2024

Serrano Isabel M, Hirose Misa, Valentine Charles C, Roesner Sharon, Schmidt Elizabeth, Pratt Gabriel, Williams Lindsey, Salk Jesse, Ibrahim Saleh, Sudmant Peter H

Abstract excerpt

Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evolution of the mitochondrial genome in different tissues throughout ageing. We used ultrasensitive duplex sequencing to profile ~2.5 million mitochondrial genomes across five...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Genome, Mitochondrial

Share to Haplotypes

Share to Mice, Inbred C57BL

Share to Mitochondria

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 38361161
DOI: 10.1038/s41559-024-02338-3
PMCID: PMC11090800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.PMID 38361161Read ↗

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout agingSemantic proximity Read ↗

A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome compositionSemantic proximity Read ↗

Mitochondrial DNA mutations in disease and aging.Semantic proximity Read ↗

A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.Semantic proximity Read ↗

Selection promotes age-dependent degeneration of the mitochondrial genomeSemantic proximity Read ↗

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.Semantic proximity Read ↗

Somatic mutations in aging and disease.Semantic proximity Read ↗

Somatic mutations, genome mosaicism, cancer and aging.Semantic proximity Read ↗

Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with ageSemantic proximity Read ↗

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice.Semantic proximity Read ↗

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.Semantic proximity Read ↗

Mitochondrial DNA mosaicism in normal human somatic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.