Article

Mitochondrial genetics defines anti-tumour immunity through mitochondrial ROS and PD-1 signalling

2025-12-10

Abstract excerpt

As central players in cell metabolism, mitochondria influence numerous aspects of health and disease, including the initiation and progression of cancer. Although mitochondrial DNA (mtDNA) mutations have been extensively documented in human cancers for decades, the functional impact of mitochondrial haplogroups on tumour biology remains largely unexplored. Here, we investigate the role of mitochondrial variability...

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Literature Corpus work: 44de1408-dfed-55d6-b298-2050223f6faf
DOI: 10.64898/2025.12.07.691020

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