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Article

Mutational landscape of a chemically-induced mouse model of liver cancer.

Journal of hepatology - 1 Oct 2018

Connor Frances, Rayner Tim F, Aitken Sarah J, Feig Christine, Lukk Margus, Santoyo-Lopez Javier, Odom Duncan T

Abstract excerpt

BACKGROUND & AIMS: Carcinogen-induced mouse models of liver cancer are used extensively to study the pathogenesis of the disease and are critical for validating candidate therapeutics. These models can recapitulate molecular and histological features of human disease. However, it is not known if the genomic alterations driving these mouse tumour genomes are comparable to those found in human tumours. Herein, we...

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Identifiers

PMID: 29958939
DOI: 10.1016/j.jhep.2018.06.009
PMCID: PMC6142872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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